期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 8, 页码 455-463出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.03.005
关键词
TRAP1; mitochondria; chaperones; cancer metabolism; ROS
类别
资金
- Progetti di Ateneo dell'Universita di Padova
- US National Cancer Institute
- Swiss National Science Foundation
- Canton de Geneve
Many tumors undergo a dramatic metabolic shift known as the Warburg effect in which glucose utilization is favored and oxidative phosphorylation is down-regulated, even when oxygen availability is plentiful. However, the mechanistic basis for this switch has remained unclear. Recently several independent groups identified tumor necrosis factor receptor-associated protein 1 (TRAP1), a mitochondrial molecular chaperone of the heat shock protein 90 (Hsp90) family, as a key modulator of mitochondria! respiration. Although all reports agree that this activity of TRAP1 has important implications for neoplastic progression, data from the different groups only partially overlap, suggesting that TRAP1 may have complex and possibly contextual effects on tumorigenesis. In this review we analyze these recent findings and attempt to reconcile these observations.
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