期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 11, 页码 632-641出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.06.005
关键词
CBX; KDM2; chromobox protein; Polycomb; PRC1
类别
资金
- Barts and The London School of Medicine and Dentistry (Queen Mary University of London, UK)
- Medical Research Council
- Medical Research Council [MC_U120085810] Funding Source: researchfish
- MRC [MC_U120085810] Funding Source: UKRI
Polycomb group proteins (PcGs) are essential epigenetic regulators that play key roles in development, pluripotency, senescence, and cancer. Recent reports have found that the composition of mammalian Polycomb repressive complex 1 (PRC1) is far more varied than previously thought. PRC1 diversity largely depends on the presence of CBX proteins, dividing them into canonical and noncanonical, the existence of redundant subunits, and different binding affinities and/or regulation. However, there is no clear insight into how many functional PRC1 complexes exist and what the biological relevance is for such diversification. In this review we focus on mammalian PRC1 and discuss the mechanisms by which canonical and non-canonical PRC1 are recruited to chromatin, their role in normal development and disease, and emerging evidence for PRC1 as a transcriptional activator.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据