期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 4, 页码 238-246出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.10.007
关键词
nuclear actin; chromatin remodeling; INO80; SWR1; NuA4
类别
资金
- Odyssey postdoctoral program
- Theodore N. Law Endowment for Scientific achievements at The University of Texas M.D. Anderson Cancer Center
- US National Cancer Institute [K22CA100017]
- US National Institute of General Medical Sciences [R01GM093104]
- Center for Cancer Epigenetics at MD Anderson Cancer Center
The mystery of nuclear actin has puzzled biologists for decades largely due to the lack of defined experimental systems. However, the development of actin-containing chromatin-modifying complexes as a defined genetic and biochemical system in the past decade has provided an unprecedented opportunity to dissect the mechanism of actin in the nucleus. Although the established functions of actin mostly rely on its dynamic polymerization, the novel finding of the mechanism of action of actin in the INO80 chromatin-remodeling complex suggests a conceptually distinct mode of actin that functions as a monomer. In this review we highlight the new paradigm and discuss how actin interaction with chromatin suggests a fundamental divergence between conventional cytoplasmic actin and nuclear actin. Furthermore, we provide how this framework could be applied to investigations of nuclear actin in other actin-containing chromatin-modifying complexes.
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