期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 10, 页码 594-602出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.06.003
关键词
lncRNA; genetic study; gene targeting; knockout; phenotype
类别
资金
- US National Institutes of Health [R01-CA118750, R01-ES023168]
Long noncoding RNAs (lncRNAs) are a pervasive and recently recognized class of genes. lncRNAs have been proposed to modulate gene expression and nuclear architecture, but their physiological functions are still largely unclear. Several recent efforts to inactivate lncRNA genes in mouse models have shed light on their functions. Different genetic strategies have yielded specific lessons about the roles of lncRNA transcription, the lncRNA transcript itself, and underlying sequence elements. Current results indicate important functions for lncRNAs in organ development, immunity, organismal viability, and in human diseases.
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