期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 11, 页码 642-650出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.07.006
关键词
histone-fold proteins; heat shock; DNA damage response; host-pathogen conflict
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
Fluctuations in the ambient environment can trigger chromatin disruptions, involving replacement of nucleosomes or exchange of their histone subunits. Unlike canonical histones, which are available only during S-phase, replication-independent histone variants are present throughout the cell cycle and are adapted for chromatin repair. The H2A.Z variant mediates responses to environmental perturbations including fluctuations in temperature and seasonal variation. Phosphorylation of histone H2A.X rapidly marks double-strand DNA breaks for chromatin repair, which is mediated by both H2A and H3 histone variants. Other histones are used as weapons in conflicts between parasites and their hosts, which suggests broad involvement of histone variants in environmental responses beyond chromatin repair.
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