期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 4, 页码 247-256出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.11.004
关键词
protein assembly/structure; cell mechanics; gene regulation; cytoskeleton; laminopathy
类别
资金
- National Institutes of Health [R01 NS059348, R01 HL082792]
- National Science Foundation CAREER award [CBET-1254846]
- Department of Defense Breast Cancer Idea Award [BC102152]
- Progeria Research Foundation [PRF2011-0035]
- Pilot Project Award
- Cornell Center on the Microenvironment and Metastasis from the National Cancer Institute [U54CA143876]
- CDMRP [545346, BC102152] Funding Source: Federal RePORTER
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1254846] Funding Source: National Science Foundation
Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide nuclear stability, help connect the nucleus to the cytoskeleton, and can modulate chromatin organization and gene expression. Nonetheless, the diverse functions of lamins remain incompletely understood. We focus here on the role of lamins on nuclear mechanics and their involvement in human diseases. Recent findings suggest that lamin mutations can decrease nuclear stability, increase nuclear fragility, and disturb mechanotransduction signaling, possibly explaining the muscle-specific defects in many laminopathies. At the same time, altered lamin expression has been reported in many cancers, where the resulting increased nuclear deformability could enhance the ability of cells to transit tight interstitial spaces, thereby promoting metastasis.
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