期刊
TRENDS IN CELL BIOLOGY
卷 23, 期 8, 页码 390-398出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.04.003
关键词
DNA targeting; plant disease; susceptibility genes; resistance genes; crystal structure; gene therapy; TAL effector nucleases
类别
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM098861] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM098861] Funding Source: Medline
Transcription activator-like (TAL) effectors are transcription factors injected into plant cells by pathogenic bacteria of the genus Xanthomonas. They function as virulence factors by activating host genes important for disease, or as avirulence factors by turning on genes that provide resistance. DNA-binding specificity is encoded by polymorphic repeats in each protein that correspond one-to-one with different nucleotides. This code has facilitated target identification and opened new avenues for engineering disease resistance. It has also enabled TAL effector customization for targeted gene control, genome editing, and other applications. This article reviews the structural basis for TAL effector-DNA specificity, the impact of the TAL effector-DNA code on plant pathology and engineered resistance, and recent accomplishments and future challenges in TAL effector-based DNA targeting.
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