期刊
TRENDS IN CELL BIOLOGY
卷 23, 期 10, 页码 465-475出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.07.004
关键词
LAR; PTP sigma; PTP delta; synapse; synaptic adhesion; receptor protein tyrosine phosphatase
类别
资金
- Korea Healthcare Technology R&D Project, Ministry for Health & Welfare Affairs, Republic of Korea [A120590, A120723]
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [NRF-2011-0028337]
- POSCO TJ Park Foundation
- Yonsei University Research Fund
The synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据