期刊
TRENDS IN CELL BIOLOGY
卷 23, 期 4, 页码 160-167出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.11.002
关键词
cell competition; cancer; Drosophila; stem cells; proliferation; cell death
类别
资金
- Medical Research Council Technology
- Cancer Research UK
- Royal Society
- Medical Research Council
- Wellcome Trust
- Cancer Research UK [12460] Funding Source: researchfish
Within tissues, cells sense differences in fitness levels and this can lead to fitter cells eliminating less fit, albeit viable, cells via competitive cell interactions. The involvement of several cancer-related genes in this phenomenon has drawn attention to a potential connection between competitive cell interactions and cancer. Indeed, initial studies found that tumor-promoting genes can turn cells into 'supercompetitors', able to kill normal cells around them. However, more recently it has been observed that cells harboring certain cancer-promoting mutations can be eliminated by surrounding normal cells, suggesting that competitive cell interactions could also have a tumor-suppressive role. These findings suggest a new view whereby tumor and host cells engage in a bidirectional tug of war, the outcome of which may have a profound impact on disease progression.
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