期刊
TRENDS IN CELL BIOLOGY
卷 23, 期 2, 页码 81-89出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.10.008
关键词
myosin-I; mechanochemistry; light chain-binding domain; motor domain
类别
资金
- National Institute of General Medical Sciences (NIGMS) [PO1 GM087253, F32 GM097889]
Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain-binding domains (LCBDs) of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and LCBDs.
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