期刊
TRENDS IN CELL BIOLOGY
卷 22, 期 7, 页码 374-380出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.04.005
关键词
autophagy; phagocytosis; entosis; engulfment; lysosome
类别
资金
- National Cancer Institute [RO1CA154649]
- Louis V. Gerstner, Jr. Young Investigators Fund
- Benjamin Friedman Research Fund
Eukaryotic cells must constantly degrade both intracellular and extracellular material to maintain cellular and organismal homeostasis. Two engulfment pathways, autophagy and phagocytosis, contribute to the turnover of intracellular and extracellular substrates by delivering material to the lysosome. Historically these are thought to be separate pathways, but recent studies have revealed the direct participation of autophagy proteins in phagocytosis. Autophagy proteins lipidate LC3 onto phagosomes and other macroendocytic vacuole membranes, and are required for lysosomal degradation of engulfed cargo, demonstrating an autophagosome-independent role for autophagy proteins in mediating the turnover of extracellular substrates. This review discusses the biological systems in which autophagy proteins have been found to regulate lysosome fusion to non-autophagic membranes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据