期刊
TRENDS IN CELL BIOLOGY
卷 22, 期 8, 页码 418-428出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.05.005
关键词
microtubule; microtubule dynamics; +TIPs; plus-end tracking; EB1
类别
资金
- National Institutes of Health grant [R01 GM079139]
- Research Facilities Improvement Program grant from the National Center for Research Resources of the National Institutes of Health [C06 RR16490]
+TIPs are a heterogeneous class of proteins that specifically bind to growing microtubule ends. Because dynamic microtubules are essential for many intracellular processes, +TIPs play important roles in regulating microtubule dynamics and microtubule interactions with other intracellular structures. End-binding proteins (EBs) recognize a structural cap at growing microtubule ends, and have emerged as central adaptors that mediate microtubule plus-end tracking of potentially all other +TIPs. The majority of these +TIPs bind to EBs through a short hydrophobic (S/T)x(I/L)P sequence motif (SxIP) and surrounding electrostatic interactions. These recent discoveries have resulted in a rapid expansion of the number of possible +TIPs. In this review, we outline our current understanding of the molecular mechanism of plus-end tracking and provide an overview of SxIP-recruited +TIPs.
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