期刊
TRENDS IN CELL BIOLOGY
卷 22, 期 8, 页码 407-417出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.05.006
关键词
aging; cancer; chaperones; lysosomes; membrane proteins; neurodegeneration; protein degradation
类别
资金
- National Institutes of Health (NIH) from the National Institute on Aging (NIA), National Institute of Neurological Disorders and Stroke (NINDS)
- Beatrice and Roy Backus Foundation
- Rainwaters Foundation
- Hirsch/Weill-Caulier Career Scientist Award
- NIH/NIA training grant
All cellular proteins undergo continuous synthesis and degradation. This permanent renewal is necessary to maintain a functional proteome and to allow rapid changes in levels of specific proteins with regulatory purposes. Although for a long time lysosomes were considered unable to contribute to the selective degradation of individual proteins, the discovery of chaperone-mediated autophagy (CMA) changed this notion. Here, we review the characteristics that set CMA apart from other types of lysosomal degradation and the subset of molecules that confer cells the capability to identify individual cytosolic proteins and direct them across the lysosomal membrane for degradation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据