期刊
TRENDS IN CELL BIOLOGY
卷 22, 期 6, 页码 311-317出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.03.002
关键词
-
类别
资金
- BBSRC
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0637] Funding Source: researchfish
- BBSRC [BBS/E/J/000C0637] Funding Source: UKRI
Concentration gradients of morphogens are critical regulators of patterning in developmental biology. Increasingly, intracellular concentration gradients have also been found to orchestrate spatial organization, but inside single cells, where they regulate processes such as cell division, polarity and mitotic spindle dynamics. Here, we discuss recent progress in understanding how such intracellular gradients can be built robustly. We focus particularly on the Pom1p gradient in fission yeast, elucidating how various buffering mechanisms operate to ensure precise gradient formation. In this case, a systems-level understanding of the entire mechanism of precise gradient construction is now within reach, with important implications for gradients in both intracellular and developmental contexts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据