期刊
TRENDS IN CELL BIOLOGY
卷 21, 期 3, 页码 141-148出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.11.006
关键词
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类别
资金
- National Institutes of Health [GM59216]
- American Cancer Society [RSG-02-039-01-CSM]
Septins are conserved GTP-binding proteins that assemble into hetero-oligomeric complexes and higher-order structures such as filaments, rings, hourglasses or gauzes. Septins are usually associated with a discrete region of the plasma membrane and function as a cell scaffold or diffusion barrier to effect cytokinesis, cell polarity, and many other functions. Recent structural studies of septin complexes have provided mechanistic insights into septin filament assembly, but key questions concerning the assembly, dynamics, and function of different septin structures remain to be answered.
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