期刊
TRENDS IN CELL BIOLOGY
卷 21, 期 8, 页码 470-480出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2011.04.007
关键词
-
类别
资金
- National Institutes of Health [R01GM068756]
- National Institute of General Medical Sciences (NIGMS) [GM068756]
Autosomal recessive primary microcephaly (MCPH) is characterized by small brain size as a result of deficient neuron production in the developing cerebral cortex. Although MCPH is a rare disease, the questions surrounding its etiology strike at the core of stem cell biology. The seven genes implicated in MCPH all encode centrosomal proteins and disruption of the MCPH gene Cdk5rap2 in mice revealed its role in neural progenitor proliferation and in maintaining normal centriole replication control. We discuss here the impact that centrosome regulation has upon neural progenitors in the developing brain. We integrate the impact of centriole replication defects with the functions of Cdk5rap2 and other MCPH proteins, propose mechanisms for progenitor loss in MCPH, and discuss links to two other microcephaly syndromes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据