期刊
TRENDS IN CELL BIOLOGY
卷 20, 期 2, 页码 79-91出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.11.004
关键词
-
类别
资金
- Academy of Finland, Juselius foundation
- European Union
- Foundation Liv och halsa
- German Research Foundation [1095/1-1, 2-1]
- NIH [DK069385, DK47918, DK52951]
- Department of Veteran Affairs Merit Award
Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multimember families that share several features, including protein abundance, significant upregulation in response to a variety of stresses, cytoprotective functions, and the phenocopying of several human diseases after IF protein or HSP mutation. We are now coming to understand that these common elements point to IFs as important cellular stress proteins with some roles akin to those already well-characterized for HSPs. Unique functional roles for IFs include protection from mechanical stress, whereas HSPs are characteristically involved in protein folding and as chaperones. Shared IF and HSP cytoprotective roles include inhibition of apoptosis, organelle homeostasis, and scaffolding. In this report, we review data that corroborate the view that IFs function as highly specialized cytoskeletal stress proteins that promote cellular organization and homeostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据