期刊
TRENDS IN CELL BIOLOGY
卷 20, 期 4, 页码 196-204出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.01.004
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类别
资金
- Fonds de la Recherche Scientifique Modicale (FRSM) [3.4.592.08.F]
- Region Wallonne de Belgique (CIBLES) [716760]
- Centre National de la Recherche Scientifique (CNRS), Paris 7 University
- Association Pour la Recherche Contre le Cancer (ARC) [3298]
- EU
Yeast permeases, that act as transporters for nutrients including amino acids, nucleobases and metals, provide a powerful model system for dissecting the physiological control of membrane protein trafficking. Modification of these transporters by ubiquitin is known to target them for degradation in the vacuole, the degradation organelle of fungi. Recent studies have uncovered the role of specific adaptors for recruiting the Rsp5 ubiquitin ligase to these proteins. In addition, the role of ubiquitin at different trafficking steps including early endocytosis, sorting into the multivesicular body (MVB) pathway and Golgi-to-endosome transit is now becoming clear. In particular, K63-linked ubiquitin chains now emerge as a specific signal for protein sorting into the MVB pathway. A complete view of the ubiquitin code governing yeast permease trafficking might not be far off.
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