期刊
TRENDS IN CELL BIOLOGY
卷 19, 期 8, 页码 414-422出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.05.002
关键词
-
类别
资金
- Deutsche Forschungsgemeinschaft
- Medical Research Council
- Human Frontiers Science Programme
- MRC [MC_U105184333] Funding Source: UKRI
- Medical Research Council [MC_U105184333] Funding Source: researchfish
Although many biochemical and structural studies have demonstrated that DNA sequences containing runs of adjacent guanines spontaneously fold into G-quadruplex DNA structures in vitro, only recently has evidence started to accumulate for their presence and function in vivo. Genome-wide analyses have revealed that functional genomic regions from highly divergent organisms are enriched in DNA sequences with G-quadruplex-forming potential, suggesting that G-quadruplexes could provide a nucleic-acid-based mechanism for regulating telomere maintenance, as well as transcription, replication and translation. Here, we review recent studies aimed at uncovering the in vivo presence and function of G-quadruplexes in genomes and RNA, with a particular focus on telomeric G-quadruplexes and how their formation and resolution is regulated to permit telomere synthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据