期刊
TRENDS IN CELL BIOLOGY
卷 19, 期 2, 页码 72-80出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.12.001
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Signal regulatory protein (SIRP)a, also known as SHPS-1 or SIRPA, is a transmembrane protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is predominantly expressed in neurons, dendritic cells and macrophages. CD47, a widely expressed transmembrane protein, is a ligand for SIRP alpha, with the two proteins constituting a cell-cell communication system. The interaction of SIRP alpha with CD47 is important for the regulation of migration and phagocytosis. Recent studies have implicated the CD47-SIRP alpha signalling pathway in immune homeostasis and in regulation of neuronal networks. Advances in the structural and functional analyses of the CD47-SIRP alpha signalling pathway now provide exciting hints of the therapeutic benefits of manipulating this signalling system in autoimmune diseases and neurological disorders.
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