期刊
TRENDS IN CELL BIOLOGY
卷 18, 期 7, 页码 330-336出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.04.006
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资金
- Howard Hughes Medical Institute Funding Source: Medline
Coat protein complex II (COPII) is a multi-subunit protein complex responsible for the formation of membrane vesicles at the endoplasmic reticulum. The assembly of this complex on the endoplasmic reticulum membrane needs to be tightly regulated to ensure efficient and specific incorporation of cargo proteins into nascent vesicles. Recent studies of a genetic disease affecting CON function, and a structural analysis of COPII subunit interactions emphasize the central role of the Sec23 subunit in COPII coat assembly. Similarly, the demonstration that Sec23 interacts physically and functionally with proteins involved in both vesicle tethering and the transport along microtubules indicates that the Sec23 subunit is crucially important in linking CON vesicle formation to anterograde transport events.
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