期刊
TRENDS IN CELL BIOLOGY
卷 18, 期 10, 页码 456-466出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.07.009
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资金
- NIGMS NIH HHS [R01 GM057438, R01 GM057438-10A1] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM057438] Funding Source: NIH RePORTER
Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario Is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure.
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