期刊
TRENDS IN CELL BIOLOGY
卷 18, 期 4, 页码 193-198出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.01.008
关键词
-
类别
资金
- NIMH NIH HHS [MH073155] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH073155] Funding Source: NIH RePORTER
LKB1 and AMP-activated protein kinase (AMPK) are serine-threonine kinases implicated in key cellular pathways, including polarity establishment and energy sensing, respectively. Recent in vivo analyses in Drosophila have demonstrated vital roles for both AMPK and LKB1 in part through the myosin regulatory light chain - in cell polarity and cell division. Evidence from mammalian experiments also supports non-metabolic functions for LKB1 and AMPK. This review examines unanticipated AMPK functions for initiating and maintaining cell polarity and completing normal cell division. The ability of AMPK to sense energy status might be coupled with fundamental cell biological functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据