期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 23, 期 5, 页码 179-183出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2012.11.002
关键词
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资金
- National Nature Science Foundation of China [30971194, 81170261]
- Special Foundation for National Outstanding Doctoral Dissertation of China [2007B7]
Vascular peroxidase 1 (VPO1) is a recently identified novel family member of peroxidases in cardiovascular system. As an enzyme that is downstream of NADPH oxidases (NOX), VPO1 functions to utilize NOX - derived hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl), a strong oxidant which is believed to greatly promote oxidative stress. Under multiple conditions, NOX is activated concomitantly with an increase in superoxide anion (O-2(is approximately equal to)) and H2O2 production. The latter is converted to HOCl by VPO1. In this process (O-2(is approximately equal to) -> H2O2 -> HOCl), the oxidant reactivities of reactive oxygen species (ROS) are significantly increased and therefore the oxidative stress is dramatically amplified. Several lines of evidence suggest that the NOX/VPO1 pathway - mediated oxidative stress plays an important role in myocardial ischemia-reperfusion injury, endothelial cell apoptosis and/or smooth muscle cell proliferation. In addition, VPO1 can be secreted into the extracellular space to participate in extracellular matrix formation, suggesting that VPO1 may also play a role in cardiovascular remodeling (such as fibrosis). This function is independent of the peroxidase activity of VPO1. (c) 2013 Elsevier Inc. All rights reserved.
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