期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 22, 期 5, 页码 133-137出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2012.07.009
关键词
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资金
- British Heart Foundation
- British Heart Foundation [RG/11/14/29056] Funding Source: researchfish
Vascular calcification is a pathological process common in patients with disorders of mineral metabolism and mediated by vascular smooth muscle cells (VSMCs). A key event in the initiation of VSMC calcification is the release of mineralization-competent matrix vesicles (MVs), small membrane-bound bodies with structural features enabling them to efficiently nucleate hydroxyapatite. These bodies are similar to MVs secreted by chondrocytes during bone development and their properties include the absence of calcification inhibitors, formation of nucleation sites, and accumulation of matrix metalloproteinases such as MMP-2. The mechanisms of MV biogenesis and loading remain poorly understood; however, emerging data have demonstrated that alterations in cytosolic calcium homeostasis can trigger multiple changes in MV composition that promote their mineralization. (Trends Cardiovasc Med 2012;22:133-137) (c) 2012 Elsevier Inc. All rights reserved.
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