期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 21, 期 7, 页码 183-187出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2012.05.007
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资金
- Institut National de la Sante et de la Recherche Medicale
- La Fondation pour la Recherche Medicale
- European Union integrated program Fighting Aneurysmal Disease
Neovascularization of atherosclerotic lesions favors their progression toward rupture. Despite this pathophysiological importance, data regarding the mechanism(s) initiating plaque neovascularization are scarce. Recent findings indicate that smooth muscle cells located underneath early aortic atheromatous lesions display a pro-angiogenic phenotype, and that lipid mediators derived from these lesions are potent inducers of this phenotypic change. Here, we discuss these new data suggesting that smooth muscle cells could be the central organizers of an angiogenic response initiated by the very first cause of the atheromatous disease, the accumulation and retention of lipids in the arterial wall. (Trends Cardiovasc Med 2011;21:183-187) (C) 2011 Elsevier Inc. All rights reserved.
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