期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 19, 期 2, 页码 61-67出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2009.04.008
关键词
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资金
- National Institutes of Health [7R01 HL060849-09, 1R01HL095010-01, 5R01HL085820-02]
K-ATP channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming (Kir6.1 and/or Kir6.2) and sulphonylurea-binding, modulatory subunits [sulfonylurea receptor (SUR) 1, 2A, or 2B]. Cardiovascular K-ATP channels are generally thought to consist of Kir6.2/SUR2A subunits (in the case of heart muscle) or Kir6.1/SUR2B subunits (smooth muscle), whereas SUR1-containing channels have well-documented roles in pancreatic insulin release. Recent data, however, demonstrated the presence of SUR1 subunits in mouse cardiac tissue (particularly in atria) and a surprising protection from myocardial ischemia/reperfusion in SUR1-null mice. Here, we review some of the extra-pancreatic roles assigned to SUR1 subunits and consider whether these might be involved in the sequelae of ischemia/reperfusion. (Trends Cardiovasc Med 2009; 19:61-67) (C) 2009, Elsevier Inc.
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