期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 18, 期 6, 页码 216-224出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2008.11.002
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资金
- NHLBI NIH HHS [T32 HL007572] Funding Source: Medline
Long-QT syndromes (LQTSs) have been described in all ages and are a significant cause of cardiovascular mortality, especially in structurally normal hearts. Abnormalities in transmembrane ion conduction channels and structural proteins produce these clinical syndromes, labeled LQT1-LQT12; however, genotype-positive patients still represent only about 70% of LQTSs. Future research will determine the etiology of the remaining cases, further risk-stratify the known genetic defects, improve current treatment options for these syndromes, and uncover novel therapies. (Trends Cardiovasc Med 2008;18:216-224) (c) 2008, Elsevier Inc.
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