期刊
TRENDS IN BIOTECHNOLOGY
卷 32, 期 6, 页码 304-311出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.03.011
关键词
endophytic fungi; red biotechnology; plant-microbe interaction; Taxol (R); endophyte biotechnology; industrial bioprocess; secondary metabolites; biosynthetic pathway; Taxol (R) biosynthetic pathway; genetic engineering; co-cultivation; bioreactor; design
资金
- International Bureau (IB) of the German Federal Ministry of Education and Research (BMBF/DLR), Germany
- Ministry of Innovation, Science, Research, and Technology of the State of North Rhine-Westphalia, Germany
- German Academic Exchange Service (DAAD
- Welcome to Africa' initiative)
- German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)
- Department of Biotechnology (DBT)
- India and the Council of Scientific & Industrial Research (CSIR), India
Taxol (R) (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol (R) producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessing similar biosynthetic potential. However, industrial-scale Taxol (R) production using fungal endophytes, although seemingly promising, has not seen the light of the day. In this opinion article, we embark on the current state of knowledge on Taxol (R) biosynthesis focusing on the chemical ecology of its producers, and ask whether it is actually possible to produce Taxol (R) using endophyte biotechnology. The key problems that have prevented the exploitation of potent endophytic fungi by industrial bioprocesses for sustained production of Taxol (R) are discussed.
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