期刊
TRENDS IN BIOTECHNOLOGY
卷 31, 期 5, 页码 16-22出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2013.03.001
关键词
microtools; biologic; microengraving; microwells
资金
- W.M. Keck Foundation
- Bill & Melinda Gates Foundation
Biologic drugs are promoting growth in the biopharmaceutical industry. Despite the clinical benefits of these drugs, the time and costs required to bring new biologics to market still are substantial. Three key challenges, among others, persist in the development of biologic drugs: namely, establishing product similarity, product toxicity, and global accessibility. New classes of microtools that facilitate the isolation and interrogation of single cells have the potential to impact each of these challenges. This opinion considers recent examples of microtools with demonstrated or potential utility to address problems in these areas. Integrating these advanced technologies into the development of new biologics could greatly reduce time and costs required to bring alternative products to market, and thus expand their global availability.
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