期刊
TRENDS IN BIOTECHNOLOGY
卷 31, 期 4, 页码 249-257出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2013.01.013
关键词
diagnostics; nanoparticles; nanotechnology; translational research; molecular imaging; oncology
资金
- Medical Research Council
- Department of Science and Technology (DST) [SR/S1/OC-67/2012]
- Council of Scientific and Industrial Research, New Delhi
- Medical Research Council [MR/J014702/1, G0601401, G0901697, MR/J010901/1, MR/K015206/1] Funding Source: researchfish
- MRC [MR/J014702/1, G0901697, G0601401, MR/K015206/1, MR/J010901/1] Funding Source: UKRI
Technologies that use surface-enhanced Raman scattering (SERS) have experienced significant growth in biomedical research during the past 4 years. In this review we summarize the progress in SERS for cancer diagnostics, including multiplexed detection and identification of new biomarkers, single-nucleotide polymorphisms, and circulating tumor cells. SERS is also used as a non-invasive tool for cancer imaging with immunoSERS microscopy, histological analysis of biopsies, and in vivo detection of tumors. We discuss the future of SERS probes compatible with multiple imaging modalities and their potential for clinical translation (e.g., endoscope-based and intraoperative imaging as tools for surgical guidance). Moreover, we highlight the potential of SERS agents for targeted drug delivery and photothermal therapy.
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