期刊
TRENDS IN BIOTECHNOLOGY
卷 30, 期 7, 页码 369-376出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2012.04.001
关键词
enzyme nano-carrier; virus-like particle; virus scaffold; bacteriophage; enzyme selection
资金
- l'Agence Nationale pour la Recherche
The cooperative organization of enzymes by cells is a key feature for the efficiency of living systems. In the field of nanotechnologies, effort currently aims at mimicking this natural organization. Nanoscale resolution and high-registration alignment are necessary to control enzyme distribution in nano-containers or on the surface of solid supports. Virus capsid self-assembly is driven by precise supramolecular combinations of protein monomers, which have made them attractive building blocks to engineer enzyme nano-carriers (ENCs). We discuss some examples of what in our opinion constitute the latest advances in the use of plant viruses, bacteriophages and virus-like particles (VLPs) as nano-scaffolds for enzyme selection, enzyme confinement and patterning, phage therapy, raw material processing, and single molecule enzyme kinetics studies.
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