期刊
TRENDS IN BIOTECHNOLOGY
卷 30, 期 11, 页码 566-574出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2012.07.004
关键词
biosensors; drug discovery; G protein-coupled receptors; high-throughput screening; cell microarrays; microfluidics
资金
- FCT, the Portuguese Foundation for Science and Technology [SFRH/BPD/66179/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/66179/2009] Funding Source: FCT
G protein-coupled receptors (GPCRs) play a key role in many physiological or disease-related processes and for this reason are favorite targets of the pharmaceutical industry. Although similar to 30% of marketed drugs target GPCRs, their potential remains largely untapped. The discovery of new leads calls for the screening of thousands of compounds with high-throughput cell-based assays. Although microtiter plate-based high-throughput screening platforms are well established, microarray and microfluidic technologies hold potential for miniaturization, automation, and biosensor integration that may well redefine the format of GPCR screening assays. This paper reviews the latest research efforts directed to bringing microarray and microfluidic technologies into the realm of GPCR-based, live-cell screening assays.
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