期刊
TRENDS IN BIOTECHNOLOGY
卷 29, 期 3, 页码 136-143出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2010.12.002
关键词
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资金
- NIH/NIGMS [5R01 GM58008]
- DOD [W81XWH-05-1-0179]
- Vanderbilt Ingram Cancer Center [P30 CA68485]
- National Foundation for Cancer Research: Vanderbilt Center for Proteomics and Drug Action
The molecular complexity of biological tissue and the spatial and temporal variation in the biological processes involved in human disease requires new technologies and new approaches to provide insight into disease processes. Imaging mass spectrometry is an effective tool that provides molecular images of tissues in the molecular discovery process. The analysis of human tissue presents special challenges and limitations because the heterogeneity among human tissues and diseases is much greater than that observed in animal models, and discoveries made in animal tissues might not translate well to their human counterparts. In this article, we briefly review the challenges of imaging human tissue using mass spectrometry and suggest approaches to address these issues.
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