期刊
TRENDS IN BIOTECHNOLOGY
卷 27, 期 1, 页码 45-52出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2008.10.005
关键词
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资金
- Victoria S. and Bradley L. Geist Foundation [20070461]
- National Science Foundation [OCE04-32479]
- National Institute of Environmental Health Sciences [P50 ES012740]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P50ES012740] Funding Source: NIH RePORTER
Marine bacteria are emerging as an exciting resource for the discovery of new classes of therapeutics. The promising anticancer clinical candidates salinosporamide A and bryostatin only hint at the incredible wealth of drug leads hidden just beneath the ocean surface. For example, if properly developed, marine bacteria could provide the drugs needed to sustain us for the next 100 years in our battle against drug-resistant infectious diseases. This review will focus on several recently discovered compounds, primarily from cyanobacteria and actinobacteria, that illustrate the tremendous potential of marine bacteria as a source of new therapeutics within the areas of oncology and infectious diseases.
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