期刊
TRENDS IN BIOTECHNOLOGY
卷 27, 期 3, 页码 179-188出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2008.11.006
关键词
-
资金
- Center for Food Safety Engineering
- US Department of Agriculture-Agricultural Research Service (USDA-ARS) [1935-42000-035]
- USDA-NRI (National Research Initiative) [2005-35603-16338]
Cell-based biosensors (CBBs) have emerged as powerful functional tools for the rapid detection of hazards and threats associated with food, agriculture, environment and biosecurity. CBBs detect the functional aspects of a host-hazard interaction and render an accurate estimation of the risks. Assessing hazard-induced physiological responses, such as receptor-ligand interactions, signal transduction, gene expression, membrane damage, apoptosis and oncosis of living sensing organisms can provide insight into the basis of toxicity for a particular hazard. This review highlights the progress made in developing mammalian CBBs for pathogens and toxins, with special emphasis on multidisciplinary approaches that combine molecular biology and microbiology with methods used in physics and engineering, which led to the development of a three-dimensional cell-culture system and high-throughput screening employing optical and electrical systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据