期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 43, 期 10, 页码 818-828出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2018.08.006
关键词
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资金
- Kanzawa Medical Research Foundation
- AMED [JP18gm5010001]
- Takeda Science Foundation
- NIH [P01HD087157, R01HD088412]
- Gates Foundation
- [KAKENHI JP17K15126]
- [JP17H01394]
- [JP 25112007]
Currently, infertility affects similar to 16% of couples worldwide. The causes are reported to involve both male and female factors, including fertilization failure between mature spermatozoa and eggs. However, the molecular mechanisms involved in each step of mammalian fertilization are yet to be fully elucidated. Although some of these steps can be rescued with assisted reproductive technologies, it is important to clarify the molecular mechanisms involved for the treatment and diagnosis of infertile couples. This review illustrates recent findings in mammalian fertilization, discovered by combining gene modification techniques with other new approaches, and aims to show how these findings will guide future research in mammalian fertilization.
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