期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 43, 期 11, 页码 896-907出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2018.09.001
关键词
-
资金
- Thailand Research Fund and Faculty of Science, Mahidol University [MRG6180251]
- Ministry of Human Resource and Development (MHRD)
- Department of Science and Technology (DST), Government of India
- Max Planck Society, Germany
Ubiquitin-like proteins (UBLs) belong to the protein family whose members share a globular beta-grasp fold structure. The archetypal member, ubiquitin, is known for its function in proteasome-mediated protein degradation. UBLs have been shown to play several crucial roles besides protein turnover, including DNA damage response, cell cycle control, cellular signaling, protein trafficking, and innate immunity activation. In the past few years, accumulating evidence illustrates that four UBLs, namely, ubiquitin, SUMO, Hub1, and Sde2, are involved in eukaryotic pre-mRNA splicing. They modify the spliceosomes and promote splicing by adding new surfaces for intermolecular interactions, thereby refining the outcome of gene expression. In this review article, we highlight recent discoveries with an emphasis on the emerging roles of UBLs in splicing regulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据