期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 39, 期 4, 页码 170-182出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.02.007
关键词
noncoding RNA; enhancer; eRNA; transcription
资金
- National Institutes of Health (NIH) [CA173903]
- Department of Defense breast cancer fellowship [BC110381]
- National Institute of General Medical Science [T32 GM007198-37, T32 GM008666]
A large portion of the human genome is transcribed into RNAs without known protein-coding functions, far outnumbering coding transcription units. Extensive studies of long noncoding RNAs (IncRNAs) have clearly demonstrated that they can play critical roles in regulating gene expression, development, and diseases, acting both as transcriptional activators and repressors. More recently, enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Here, we review emerging evidence suggesting that at least some eRNAs contribute to enhancer function. We discuss these findings with respect to potential mechanisms of action of eRNAs and other ncRNAs in regulated gene expression.
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