期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 39, 期 3, 页码 130-140出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.01.002
关键词
acidic phospholipids; ionic protein-lipid interaction; Ca2+
资金
- National Basic Research Program of China (973 Program) [2011CB910901, 2012CB910804, 2014CB541903]
- National Science Foundation of China [31070738, 31370860]
- Chinese Academy of Sciences [KSCX2-EW-J-11]
- Hundred Talents Program
- Strategic Priority Research Program [XDB08020100]
Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which can have functional consequences for the protein. The list of proteins regulated by ionic protein-lipid interaction has been quickly expanding, and now includes membrane proteins, cytoplasmic soluble proteins, and viral proteins. Here we review how acidic phospholipids in the plasma membrane regulate protein structure and function via ionic interactions, and how Ca2+ regulates ionic protein-lipid interactions via direct and indirect mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据