期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 39, 期 7, 页码 310-318出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.05.002
关键词
DNA methylation; epigenetic inheritance; DNA methyltransferase specificity; DNA methyltransferase regulation; stochastic model
资金
- DFG [JE 252/10, JE 252/15]
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early development, and methylation at hemimethylated CpG sites is specifically maintained by the Dnmt1 maintenance methyltransferase. However, substantial experimental evidence from the past decade indicates that this simple model needs to be revised. DNA methylation can be described by a dynamic stochastic model, in which DNA methylation at each site is determined by the local activity of DNA methyltransferases (Dnmts), DNA demethylases, and the DNA replication rate. Through the targeting and regulation of these enzymes, DNA methylation is controlled by the network of chromatin marks.
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