期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 39, 期 3, 页码 112-120出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.12.007
关键词
cancer; selenium; selenocysteine; selenoproteins
资金
- Intramural Research Program of the National Institutes of Health (NIH)
- National Cancer Institute
- Center for Cancer Research
- NIH
The many biological and biomedical effects of selenium are relatively unknown outside the selenium field. This fascinating element, initially described as a toxin, was subsequently shown to be essential for health and development. By the mid-1990s selenium emerged as one of the most promising cancer chemopreventive agents, but subsequent human clinical trials yielded contradictory results. However, basic research on selenium continued to move at a rapid pace, elucidating its many roles in health, development, and in cancer prevention and promotion. Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions.
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