期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 38, 期 10, 页码 494-506出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.07.004
关键词
stress granules; translation; cell signaling; protein aggregation; intrinsically disordered
资金
- NCI NIH HHS [R01 CA168872] Funding Source: Medline
Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors, and specific RNA-binding proteins. In addition many signaling proteins are recruited to SGs and/or influence their assembly, which is transient, lasting only until the cells adapt to stress or die. Beyond their role as mRNA triage centers, we posit that SGs constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes. As signaling centers, SG formation communicates a 'state of emergency', and their transient existence alters multiple signaling pathways by intercepting and sequestering signaling components. SG assembly and downstream signaling functions may require a cytosolic phase transition facilitated by intrinsically disordered, aggregation-prone protein regions shared by RNA-binding and signaling proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据