期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 38, 期 2, 页码 85-93出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.11.005
关键词
detergent(s); solubilization; liposomes; bilayers; mixed micelles; spontaneous curvature; phospholipids; cholesterol
资金
- Spanish Ministry of Economy [BFU 2007-62062, BFU 2011-28566]
- Lady Davis Fund
- Bizkaia-Xede
Although detergents are routine tools in biomembrane research, their use remains empirical. We propose that solubilization is the result of a balance between two parameters: (i) the energy associated with bending of phospholipid monolayers into a curved micellar surface, and (ii) the energy associated with filling the void in the center of the resultant mixed micelle. In this review, we show that reliable data on the phase boundaries, and their dependence on various conditions, are consistent with this hypothesis, even if the data might have been interpreted differently. Although most of the experimental data discussed here were obtained with the non-ionic detergent Triton X-100, the conclusions should be applicable to a wide variety of detergents.
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