期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 38, 期 9, 页码 461-466出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.06.011
关键词
ATRX; G4-quadruplex DNA; DNA replication; alternative lengthening of telomeres
资金
- Medical Research Council
- University of Oxford
- Medical Research Council [MC_UU_12009/3, MC_U137961147, G1000801j] Funding Source: researchfish
- MRC [MC_UU_12009/3, MC_U137961147] Funding Source: UKRI
The regulation of chromatin structure is of paramount importance for a variety of fundamental nuclear processes, including gene expression, DNA repair, replication, and recombination. The ATP-dependent chromatin-remodelling factor ATRX (alpha thalassaemia/mental retardation X-linked) has emerged as a key player in each of these processes. Exciting recent developments suggest that ATRX plays a variety of key roles at tandem repeat sequences within the genome, including the deposition of a histone variant, prevention of replication fork stalling, and the suppression of a homologous recombination-based pathway of telomere maintenance. Here, we provide a mechanistic overview of the role of ATRX in each of these processes, and propose how they may be connected to give rise to seemingly disparate human diseases.
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