期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 38, 期 6, 页码 283-291出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.03.006
关键词
human mitochondria; transcriptional regulation; transcription factor; RNA polymerase; transcription factor A, mitochondrial
资金
- U.S. NIH [F32DK091042, HL-059655]
The human genome comprises large chromosomes in the nucleus and mitochondria! DNA (mtDNA) housed in the dynamic mitochondria! network. Human cells contain up to thousands of copies of the double-stranded, circular mtDNA molecule that encodes essential subunits of the oxidative phosphorylation complexes and the rRNAs and tRNAs needed to translate these in the organelle matrix. Transcription of human mtDNA is directed by a single-subunit RNA polymerase, POLRMT, which requires two primary transcription factors, TFB2M (transcription factor B2, mitochondria!) and TFAM (transcription factor A, mitochondria!), to achieve basal regulation of the system. Here, we review recent advances in understanding the structure and function of the primary human transcription machinery and the other factors that facilitate steps in transcription beyond initiation and provide more intricate control over the system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据