期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 11, 页码 457-459出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.08.005
关键词
miRNA; noncoding RNA; nucleus; Argonaute; exportin; importin
资金
- National Natural Science Foundation of China [81101330, J1103512]
- Natural Science Foundation of Jiangsu Province [BK2011013]
- Fundamental Research Funds for the Central Universities [1107020839]
It has long been assumed that miRNAs can only target protein-coding mRNAs in the cytoplasm. Recent studies, however, reveal miRNAs are also transported from the cytoplasm to the nucleus, where they function in a noncanonical manner to regulate noncoding RNAs. Here, we highlight the working model of these noncanonical miRNAs.
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