期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 9, 页码 373-380出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.06.005
关键词
reactive oxygen species; biocatalysis; oxidase; monooxygenase; oxidative damage; flavin; mechanism
资金
- European Union (Project Oxygreen) [212281]
- European Union (MAHEVA-ERASMUS)
- Fondazione Cariplo [2010.0778]
- Associazione Italiana Ricerca sul Cancro [IG-11342]
- Thailand Research Fund [BRG5480001]
- Faculty of Science, Mahidol University
The reaction of flavoenzymes with oxygen remains a fascinating area of research because of its relevance for reactive oxygen species (ROS) generation. Several exciting recent studies provide consistent mechanistic clues about the specific functional and structural properties of the oxidase and monooxygenase flavoenzymatic systems. Specifically, the spatial arrangement of the reacting oxygen that is in direct contact with the flavin group is emerging as a crucial factor that differentiates between oxidase and monooxygenase enzymes. A challenge for the future will be to use these emerging concepts to rationally engineer flavoenzymes, paving the way to new research avenues with far-reaching implications for oxidative biocatalysis and metabolic engineering.
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