期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 5, 页码 206-214出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2012.03.001
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资金
- European Community [223545 'MM2M']
- Swiss National Science Foundation [310030B-133123]
- Swiss National Science Foundation (SNF) [310030B_133123] Funding Source: Swiss National Science Foundation (SNF)
A considerable surge of interest in the mismatch repair (MMR) system has been brought about by the discovery of a link between Lynch syndrome, an inherited predisposition to cancer of the colon and other organs, and malfunction of this key DNA metabolic pathway. This review focuses on recent advances in our understanding of the molecular mechanisms of canonical MMR, which improves replication fidelity by removing misincorporated nucleotides from the nascent DNA strand. We also discuss the involvement of MMR proteins in two other processes: trinucleotide repeat expansion and antibody maturation, in which MMR proteins are required for mutagenesis rather than for its prevention.
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