期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 37, 期 3, 页码 85-91出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2011.11.004
关键词
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资金
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 746]
- Excellence Initiative of the German Federal & State Governments [EXC 294]
- Gottfried Wilhelm Leibniz Program
- Landesforschungspreis Baden-Wurttemberg
- Bundesministerium fur Bildung und Forschung
Mitochondria, the powerhouses of the cell, import most of their proteins from the cytosol. It was originally assumed that mitochondria imported precursor proteins via a general pathway but recent studies have revealed a remarkable variety of import pathways and mechanisms. Currently, five different protein import pathways can be distinguished. However, the import machineries cooperate with each other and are connected to other systems that function in the respiratory chain, mitochondrial membrane organization, protein quality control and endoplasmic reticulum-mitochondria junctions. In this Opinion, we propose that mitochondrial protein import should not be seen as an independent task of the organelle and that a network of cooperating machineries is responsible for major mitochondrial functions.
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